削减
发表于 2025-3-28 18:08:58
Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases, their major glycating agents. Glycation is a non-enzymatic covalent reaction discovered by Louis Camille Maillard in 1912, between reactive carbonyls (reducing sugars and glyoxals) and amino acids (cysteine, arginine and lysine), which inactivates proteins. By degrading Maillard adducts formed betw
Hiatus
发表于 2025-3-28 22:46:57
,DJ-1 as a Biomarker of Parkinson’s Disease,s been identified as a causative gene of a familial form of Parkinson’s disease, ., and plays a significant role in antioxidative defense, protecting cells from oxidative stress. A cysteine residue of DJ-1 at position 106 (Cys-106) is preferentially oxidized under oxidative stress. This reactive Cys
Dorsal-Kyphosis
发表于 2025-3-29 02:27:54
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Spartan
发表于 2025-3-29 06:58:11
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表被动
发表于 2025-3-29 07:49:35
DJ-1 as a Therapeutic Target Against Cancer,egulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1
变异
发表于 2025-3-29 12:50:50
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backdrop
发表于 2025-3-29 18:24:15
P. Nisha,Manuel Thomas,T. K. Neelima thioredoxin and glutathione pathways, which in turn mediate an antioxidant protective function. Crosstalk between DJ-1 and both the thioredoxin and glutathione systems has also been identified. Thioredoxin reduces a cysteine residue on DJ-1 to modulate its activity, while glutaredoxin1 de-glutathio
Dorsal
发表于 2025-3-29 20:05:43
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共同生活
发表于 2025-3-30 02:38:08
Aquatic Lectins: An Overview (A Paradigm). It also modulates autophagy through the ERK, Akt, or the JNK/Beclin1 pathways. In addition, DJ-1 regulates the transcription of genes essential for male reproductive function, such as spermatogenesis, by relaying nuclear receptor androgen receptor (AR) signaling. In this chapter, we summarize the
fiction
发表于 2025-3-30 06:45:56
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