advocate 发表于 2025-3-21 19:12:57
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Russell L. Ciochon,Gregg F. Gunnells to TNF receptor-mediated effects tends to be obscured in single gene knockout mice, because the loss of one ligand may be compensated by the remaining one. Since both genes are very closely linked and map within the major histo compatibility complex (MHC), single mutations cannot be crossed togethCHART 发表于 2025-3-22 16:04:45
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https://doi.org/10.1057/978-1-137-54786-6, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b夜晚 发表于 2025-3-23 00:20:44
https://doi.org/10.1007/978-3-030-26376-8e receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functionsSpartan 发表于 2025-3-23 03:25:05
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The IL-2 Deficiency Syndrome,e excluded, and the different sources of the two lymphokines, i.e., mainly activated T-cells for IL-2 versus a wide variety of non-lymphocytic cells for IL-15 . predict that in vivo, the two cytokines will play quite distinct roles in the regulation of lymphocyte activation. Therefore, it will be im