占卜者 发表于 2025-3-23 11:47:54
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IL-6 Gene Knockout Mice,, oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) display overlapping activities with IL-6 that may be explained by a common receptor signal transducing component (gp 130). In order to clarify the unique functions of IL-6 in vivo, we have disrupted the murine IL-6 gene in the second exon b大门在汇总 发表于 2025-3-24 03:29:26
Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Commone receptor complexes for IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1) .. The discovery of this shared signal transducer, gp 130, helps to explain how these different cytokines can mediate overlapping biological functionsPreamble 发表于 2025-3-24 07:56:11
,Phenotypes of TGFß Knockout Mice, amino acid precursor. It has the characteristics of a secretory polypeptide, contains a hydrophobic signal sequence for translocation across the endoplasmic reticulum, and is glycosylated. The precursor cleavage site is a sequence of four basic amino acids immediately preceding the bioactive domain易于 发表于 2025-3-24 11:27:20
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Contemporary Immunologyhttp://image.papertrans.cn/d/image/242629.jpgfiscal 发表于 2025-3-25 02:40:57
https://doi.org/10.1057/9781137513441 IL-1Ra is a specific receptor antagonist. IL-1α and IL-1β are synthesized as precursor molecules, without leader sequences. The molecular weight of each precursor is 31 kDa. Processing of IL-1α or IL-1β to “mature” forms of 17 kDa requires specific cellular proteases.