摇晃
发表于 2025-3-27 00:23:59
ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?, common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protein aggregation. The unfolded protein response (UPR) embodies a major element of the proteostasis network triggered by endoplasmic re
拥护者
发表于 2025-3-27 01:22:58
Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling,ns in the Endoplasmic Reticulum (ER) lumen, thus causing ER stress. When this happens, an adaptive mechanism named the Unfolded Protein Response (UPR) is triggered to help the cell cope with this change and restore protein homeostasis in the ER. Sequentially, one would expect that the activation of
Substance-Abuse
发表于 2025-3-27 07:15:23
ER Protein Quality Control and the Unfolded Protein Response in the Heart,in response to a variety of physiological and pathological conditions; this growth challenges endoplasmic reticulum-protein quality control (ER-PQC), a major feature of which includes the unfolded protein response (UPR). ER-PQC and the UPR in cardiac myocytes growing under physiological conditions,
过多
发表于 2025-3-27 11:57:13
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小母马
发表于 2025-3-27 14:56:09
Whistleblowers, Managers and the State,both stress-dependent and -independent control of UPR activity. Such tools provide new opportunities to perturb the UPR and thereby study mechanisms for maintaining proteostasis in the secretory pathway. Numerous observations now hint at the therapeutic potential of UPR modulation for diseases relat
craven
发表于 2025-3-27 19:10:43
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消音器
发表于 2025-3-27 22:08:08
El Teatro Español (Federico García Lorca), altered metabolism, increased inflammation and tumor-immune infiltration, invasion and metastasis, and angiogenesis, defined as “the hallmarks of cancer”, can be regulated by the UPR machinery. At the same time, new potential therapeutic interventions applicable to different kinds of cancers are b
伤心
发表于 2025-3-28 05:13:17
El Teatro Español (Federico García Lorca)d during myocardial pathology. This chapter will discuss the physiological and pathological conditions unique to the heart that involves ER-PQC, and whether the UPR is adaptive or maladaptive under these circumstances.
Cholecystokinin
发表于 2025-3-28 08:59:44
Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response,both stress-dependent and -independent control of UPR activity. Such tools provide new opportunities to perturb the UPR and thereby study mechanisms for maintaining proteostasis in the secretory pathway. Numerous observations now hint at the therapeutic potential of UPR modulation for diseases relat
埋伏
发表于 2025-3-28 14:17:49
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