ASSAY
发表于 2025-3-23 10:37:50
The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Drivingthat in immune cells, the UPR has acquired functions that stretch far beyond its original scope. In this review, we will discuss the role of the UPR in the immune system and highlight the plasticity of this signaling cascade throughout immune cell development.
表被动
发表于 2025-3-23 17:21:39
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Lucubrate
发表于 2025-3-23 19:04:05
Whistleblowers, Managers and the State,ollectively termed the unfolded protein response (UPR). By the action of the transmembrane signal transducers IRE1, PERK, and ATF6, the UPR induces networks of genes whose products alleviate the burden of protein misfolding. The UPR also plays instructive roles in cell differentiation and developmen
amphibian
发表于 2025-3-24 00:38:30
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Flustered
发表于 2025-3-24 04:58:35
The Demographic and Economic Perspective,is elaborate function is coordinated by the unfolded protein response (UPR), a stress-activated cellular program that governs proteostasis. In multicellular organisms, cells have adopted specialized functions, which required functional adaptations of the ER and its UPR. Recently, it has become clear
Paleontology
发表于 2025-3-24 10:07:39
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choleretic
发表于 2025-3-24 14:09:38
El Teatro Español (Federico García Lorca)d by various intrinsic/extrinsic stimuli challenges the protein-folding capacity of the ER, leading to an ER dysfunction, called ER stress. Cells have developed a defensive response to adapt and/or survive in the face of ER stress that may be detrimental to cell function and survival. When exposed t
600
发表于 2025-3-24 18:14:11
El Teatro Español (Federico García Lorca) common origin, where disruption of intracellular mechanisms related to protein homeostasis (here termed proteostasis) control during aging may result in abnormal protein aggregation. The unfolded protein response (UPR) embodies a major element of the proteostasis network triggered by endoplasmic re
错误
发表于 2025-3-24 22:29:13
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裤子
发表于 2025-3-25 01:01:41
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