AGATE
发表于 2025-3-28 16:06:42
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不妥协
发表于 2025-3-28 19:59:35
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疏远天际
发表于 2025-3-29 00:36:10
Assessing and Engineering Antibody Stability Using Experimental and Computational Methods molecules with the desired conformational and colloidal stability. This chapter introduces our methods to computationally characterize an antibody Fab fragment, propose stabilizing variants, and then experimentally verify these predictions.
A简洁的
发表于 2025-3-29 05:47:09
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scrutiny
发表于 2025-3-29 10:58:55
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unstable-angina
发表于 2025-3-29 12:35:30
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Ambiguous
发表于 2025-3-29 18:25:53
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挑剔为人
发表于 2025-3-29 21:56:42
Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations to improve the stability and have later been validated by experiments. Our protocol extends beyond the application on sdAbs, as it is also suitable for other proteins and to determine the interfacial stability between protein and ligand.
adumbrate
发表于 2025-3-30 02:49:11
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空中
发表于 2025-3-30 05:38:27
Structure-Based Optimization of Antibody-Based Biotherapeutics for Improved Developability: A Practif candidates arising from target affinity screening and to optimize lead candidates for developability. Methods for modeling antibody structures from sequence and detecting post-translational modifications and chemical degradation liabilities are also discussed.