Aesthete
发表于 2025-3-25 06:18:45
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同义联想法
发表于 2025-3-25 07:57:52
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Instrumental
发表于 2025-3-25 13:11:28
https://doi.org/10.1057/9780230233850s. This method measures the .-value, the fraction of the native contacts, along the trajectory of high-temperature MD simulations starting from the experimental X-ray structure. We show a good correlation between the .-value and the experimental melting temperature (.) in seven sdAbs. Assessing the
coltish
发表于 2025-3-25 18:01:45
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Colonnade
发表于 2025-3-25 22:11:28
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yohimbine
发表于 2025-3-26 02:37:39
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choroid
发表于 2025-3-26 07:06:38
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袋鼠
发表于 2025-3-26 08:37:09
Anna Kicinger,Agnieszka Weinar,Agata Górnydies. A fundamental prerequisite is the identification of antigenic regions that are most prone to interact with antibodies, namely, B-cell epitopes. Here, we describe an efficient structure-based computational method for epitope prediction, called MLCE. In this approach, all that is required is the
漂白
发表于 2025-3-26 14:52:27
Anna Kicinger,Agnieszka Weinar,Agata Górnys used to study and characterize them. Effective design and engineering of antibodies for therapeutic purposes are heavily dependent on knowledge of the structural principles that regulate antibody–antigen interactions. Several experimental techniques such as X-ray crystallography, cryo-electron mic
狂怒
发表于 2025-3-26 17:31:12
Anna Kicinger,Agnieszka Weinar,Agata Górnyhow to use such data to understand adaptive immune responses to disease. Infectious disease is of particular interest because the antigens driving such responses are often known to some extent. Here, we describe tips for gathering data and cleaning it for use in downstream analysis. We present a met