urinary-tract
发表于 2025-3-21 17:25:46
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CORE
发表于 2025-3-21 23:30:01
The Pathobiology of Pig-to-Primate Xeno.: A Historical Reviewthat bind to antigens expressed on the transplanted pig organ (the most important of which is galactose-α1,3-galactose ) and activate the complement cascade, which results in rapid destruction of the graft, a process known as hyperacute rejection. High levels of elicited anti-pig IgG may develo
regale
发表于 2025-3-22 02:29:59
Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation?nograft. To answer this question, we have searched the literature. We primarily limited our review to the clinically relevant pig-to-nonhuman primate (NHP) model, and found five studies that explored this topic. No NHP that had received a pig graft developed antibodies to alloantigens, and in vitro
话
发表于 2025-3-22 07:58:11
Sensitization to Human Leukocyte Antigens and Xenotransplantationso the dominant polymorphic proteins targeted in allograft rejection. Sensitized patients with high levels of panel-reactive anti-HLA antibody (PRA) are at risk of early allograft injury, rejection, and reduced allograft survival, and they often experience prolonged waiting times prior to transplant
诱使
发表于 2025-3-22 10:48:31
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褪色
发表于 2025-3-22 13:30:26
Cardiac Xenotransplantation in Nonhuman Primates.g., in the neck or abdomen, of the recipient. This allowed observations to be made of rejection and of how this could be prevented by immunosuppressive therapy and/or immunomodulation procedures, e.g., anti-pig antibody adsorption. With the development of genetic engineering techniques, and the ava
褪色
发表于 2025-3-22 17:16:56
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节省
发表于 2025-3-22 23:31:56
Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Desigssigned regulatory responsibility for Xenotransplantation to the Center for Biologics Evaluation and Research. As a novel therapeutic, the Investigational New Drug Application will likely be subjected to review by a review committee assembled by the Office of Cellular, Tissue, and Gene Therapies. Th
NOTCH
发表于 2025-3-23 04:28:25
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贪婪地吃
发表于 2025-3-23 06:34:20
Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejectionplant. Patients who are sensitized to allo-human leukocyte antigen (HLA) have a primed humoral and cellular immune response, and many will have preformed donor-specific antibody (DSA). Desensitization protocols and treatment of antibody-mediated rejection in allotransplantation have made great progr