消毒 发表于 2025-3-30 08:23:51
https://doi.org/10.1007/978-1-4684-5985-2 us a clue to the biological role of this posttranslational protein modification in chromatin. However, the phenotype of a genetically engineered cell under- or overexpressing components of the poly-ADP-ribosylation system may be difficult to interpret, since these cells, if viable at all, may exhibAIL 发表于 2025-3-30 15:57:32
https://doi.org/10.1007/978-1-4684-5985-2chemical agents (e.g. bleomycin) that they induce chromosome aberrations at first mitosis following exposure of a cell in the G1 phase of the cell cycle, whereas agents such as UV that induce almost entirely single-stranded lesions (principally thymine dimers, which are converted to single-strand brInfelicity 发表于 2025-3-30 17:43:02
The Politics of Life and Death,). Analyses of Bryant and Christie (1989) have shown that the uptake of REs using the “pellet technique” is dependent on the shipping buffer in which the REs are suspended. The authors assume that “this may result from a combination of hypertonic shock and the detergent present in the shipping buffeDictation 发表于 2025-3-30 22:36:00
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Heterogeneity of DNA Repair in Relation to Chromatin Structure,e repair of ultraviolet light-induced photoproducts has been intensively studied in a variety of mammalian cells and in most cases UV-induced cytotoxicity can be correlated to the extent of unscheduled DNA synthesis or removal of pyrimidine dimers from the nuclear DNA. For example variation in UV-inFeigned 发表于 2025-3-31 21:31:33
The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?,nknown (for review see Althaus and Richter 1987). In 1985 Ueda and Hayaishi stated that “… a major difficulty in obtaining direct and definitive evidence for the role(s) of poly-ADP-ribosylation has stemmed from the complexity of systems used. A major breakthrough would therefore be expected by recochalice 发表于 2025-3-31 23:00:46
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