Pander
发表于 2025-3-23 12:31:29
https://doi.org/10.1007/978-1-4684-5985-2bonds. In an irradiated cell, therefore, damage can occur at any point in the structure of DNA. As a result of this high energy per ionizing event, radiation is able to induce a variety of lesions in the DNA of cells which can be grouped into those involving damage to the base moeity without breakag
leniency
发表于 2025-3-23 13:51:50
https://doi.org/10.1007/978-1-349-20304-8cleave DNA to generate either blunt-end or cohesive-end double-strand breaks. The role of DNA double-strand breaks in chromosome damage has long been a matter of some controversy (see Bryant 1988). By introducing restriction endonucleases into cells and examining their cytogenetic effects, investiga
谷物
发表于 2025-3-23 19:53:57
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懒惰民族
发表于 2025-3-23 22:38:08
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容易懂得
发表于 2025-3-24 05:11:48
https://doi.org/10.1007/978-3-662-05181-8 breakage syndromes such as ataxia telangiectasia and xeroderma pigmentosum or constitutional chromosomal abnormalities are found to be at high risk for the development of malignancy (Lejeune et al. 1959; Ray and German 1981). Similarly, individuals who have increased exposure to clastogenic agents
无瑕疵
发表于 2025-3-24 08:37:50
René Motais,Hélène Guizouarn,Franck Borgesee, among others, ataxia telangiectasia, Bloom’s syndrome, familial polyposis, Fanconi’s anemia, Gardner’s syndrome, and xeroderma pigmentosum (Setlow 1978). We have shown that skin fibroblasts from affected individuals or individuals with a family history of cancer, compared to cells from clinically
镇痛剂
发表于 2025-3-24 13:59:51
George J. Brewer (Conference Chairman)ubsequently, the emphasis was shifted to mutation as a cellular process in which the primary lesion was extensively modified by enzymatic DNA-repair systems constitutively present in the cell (Auerbach 1976). Finally, over the past 15 years, considerable interest has been focused on inducible cellul
Vasodilation
发表于 2025-3-24 17:13:01
Red Cell Metabolism and Functionuce a series of responses that are often related to the repair of the initial damage (see Boothman et al. 1989). One type of induced repair, which was first found in ., has been called the adaptive reponse (Samson and Cairns 1977). In these experiments with bacteria, and in later experiments with ma
只有
发表于 2025-3-24 19:29:38
Red Cell Metabolism and Functione response was first reported by Samson and Cairns (1977) in . as an inducibile form of DNA repair acting on alkylation damage, in which the bacterial cells that had been exposed to low levels of alkylating agents became less susceptible to the subsequent high doses of the same and other compounds.
Ambulatory
发表于 2025-3-25 00:36:52
https://doi.org/10.1007/978-3-642-67059-6 To date, several methods have been proposed for the chromosome-based dose assessment (IAEA 1986). However, in spite of the growing importance in the risk assessment, the dose-yield kinetics of chromosome aberrations and their implications for dose assessment are not well established in exposures to