归纳 发表于 2025-3-21 18:29:00
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Introduction hovers over his retort planning what to brew up next. His thinking may be directed by analogy with known active structures or by fashionable biochemical pathways, but beyond this the medicinal chemist needs a vision and a feel for the target.Offstage 发表于 2025-3-22 05:01:06
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Drug Discovery: Nature’s Approach without causing damage to mammalian cells. Herein we will cover some of the current research in the discovery and evaluation of new antifungal agents from natural sources, and also the current methodology used in their biological evaluation as potential clinical candidates. In addition, a survey ofATOPY 发表于 2025-3-22 16:07:18
Screening and Evaluation In Vivocompounds in the body and the different sites of fungal location, some indication of the . spectrum of activity is desirable; e.g. although . is basically susceptible to amphotericin B and systemic infections do show a response to treatment, vaginal ones do not. Other compounds will be basically narATOPY 发表于 2025-3-22 20:55:11
Introductionnd regulatory procedures burgeoned in the hope of avoiding a similar situation in the future. Sally Eardley, a colleague from ICI, has written a delightful chapter (11) chronicling regulatory developments over the past 3500 years. Although she has had no experience with antifungal drugs, I find her万灵丹 发表于 2025-3-22 22:36:03
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Formulationmonstrated how tricks of formulation can reduce potential toxicity without affecting antifungal activity and thus increase the utility of the compound. It is in the area of topical formulation that most scope exists for presenting the compound in a way in which it will reach the fungus, persist unti