确定无疑
发表于 2025-3-26 23:38:46
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通便
发表于 2025-3-27 03:04:55
Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry, identifier PXD035183, this enables the straightforward implementation of the method by scientists with a basic biochemistry and mass spectrometry background. We describe how the procedure can easily be adapted to other protein samples and small molecules.
manifestation
发表于 2025-3-27 08:42:45
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羊齿
发表于 2025-3-27 11:24:10
Annotation of the Effect of Chemogenomic Compounds on Cell Health Using High-Content Microscopy in rotocol monitors cells during a time course of 48 h using osteosarcoma cells, human embryonic kidney cells, and untransformed human fibroblasts as an example. The described protocol can be easily established and it can be adapted to other cell lines or other parameters important for cellular health.
我没有命令
发表于 2025-3-27 15:16:46
Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitor-reactive inhibitors based on two orthogonal approaches. We illustrate the use of clickable alkyne probes for in-gel fluorescence and mass spectrometry studies using a series of therapeutic XPO1 inhibitors as an example.
陶瓷
发表于 2025-3-27 19:03:50
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眼界
发表于 2025-3-28 00:47:15
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Intervention
发表于 2025-3-28 04:48:55
https://doi.org/10.1007/978-3-319-66637-2positories to increase target coverage and data accuracy. Here, we present a workflow to generate custom datasets from public databases for mining chemogenomic compound candidates. The compiled set provides flags for differences in structural and bioactivity data and enables rapid extraction of potent and selective bioactive compounds.
推测
发表于 2025-3-28 07:30:15
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指令
发表于 2025-3-28 10:31:41
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