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Identification of Receptors Using Direct Radioligand Binding Techniques,tes for these radiolabeled agents in target tissues where they elicit a physiological effect. This chapter will describe methods for the identification of radioligand binding sites and for obtaining data to establish whether or not the observed binding sites represent the physiological “receptor” fo垄断 发表于 2025-3-22 06:28:48
Complex Binding Phenomena, linear transformations of binding data were derived assuming that a reversible bimolecular reaction occurred between ligand and receptor and that this interaction obeyed mass action law, namely *.. Consequently, when data transformations such as the Scatchard plot are nonlinear, when Hill coefficie加剧 发表于 2025-3-22 11:49:38
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Biochemical Correlates of the Topographical Fate of Ligand-Receptor Complexes,gand and receptor has been conceptualized in a rather static framework, as if the receptor molecule remains unchanged in isolated membrane preparations or in detergent-solubilized solution, even after receptor occupancy. This may or may not be true. However, when ligand binding to intact cells is mePRO 发表于 2025-3-22 18:46:39
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