松紧带
发表于 2025-3-30 10:11:05
Mitotic Checkpoint and Chromosome Instability in Cancerpromoting complex/cyclosome (APC/C). The CIN phenotype of many cancer cell lines may be attributed to the lack of a robust mitotic checkpoint as these cells fail to arrest in response to microtubule inhibitors such as taxol and nocodazole. Interestingly, mutations in the essential mitotic checkpoint