floaters 发表于 2025-3-25 05:07:21
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Molecular Biology and Pharmacology of Recombinant Adenosine Receptors, but can activate phospholipase C via G protein βγ subunits, but the A. receptor desensitizes much more slowly. The A. and A. receptors both couple to Gs, but theA. receptor also can couple to Gq to mobilize calcium.inconceivable 发表于 2025-3-25 16:03:46
Regulation of Adenosine Receptor Subtypes and Cardiac Dysfunction in Human Heart Failure,RNA was not detectable. However, A.-adenosine receptor gene expression was increased by about 60% in patients with dilated cardiomyopathy. Thus, the A.-upregulation may indicate a pathophysiological role for adenosine and adds therefore to the increasingly complex picture of molecular alterations in heart failure.凶猛 发表于 2025-3-25 22:31:44
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Robert Boardman,James F. Keeleycellular adenosine concentration is normally very low and adenosine is continuously formed extracellularly from released adenine nucleotides, the concentration gradient for adenosine in the normoxic heart is from extracellular to intracellular. This gradient is rapidly reversed during hypoxia or pharmacological inhibition of adenosine kinase.aristocracy 发表于 2025-3-26 13:57:25
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Vascular Biology and Pharmacology of Adenosine Receptors,les of adenosine (Tucker and Linden, 1992; Muller et al., 1996; Olsson, 19%; Ongini and Fredholm, 1996; Feoktistov and Biaggioni, 1997) allow the authors to focus this review on important new developments that have occurred over the past two or three years. Readers wanting a broader understanding should consult those earlier articles.