万灵丹
发表于 2025-3-30 11:08:28
Biphasic positive inotropic actions of ouabain on rat, guinea-pig and cat heart: a mathematical dessic action of ouabain a hypothetical model for the mechanism(s) of action of ouabain is discussed. Mathematical description of this model is based on the existence of two different receptor-types for ouabain. It is suggested that sarcolemmal-bound calcium may play an important role in both mechanism
frenzy
发表于 2025-3-30 16:18:27
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Camouflage
发表于 2025-3-30 19:35:35
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排名真古怪
发表于 2025-3-31 00:38:16
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修饰语
发表于 2025-3-31 03:13:04
Nonprofit-Organisationen als Arbeitgeberccording to recent observations the activity of the sodium/potassium-ATPase or its concentration, and therefore the concentration of binding sites can increase in some tissues after long term treatment with cardiac glycosides. This might explain the occasionally observed tolerance to digitalis glycosides.
arbiter
发表于 2025-3-31 08:36:26
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outskirts
发表于 2025-3-31 10:35:01
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Geyser
发表于 2025-3-31 13:39:02
H.-J. Guder,Werner Kunz,Sabine Westditions suggested that lowering Ca. has qualitative and quantitative effects. Low Ca. concentrations increased the sensitivities to ouabain and the amplitudes of both the enzyme inhibition and the positive inotropic effects.
捏造
发表于 2025-3-31 21:21:57
Two receptors for cardiac glycosides in the heart,owever, is only inhibited at toxic glycoside concentrations. Thus, in rat and guinea pig heart there exist at least two different digitalis receptors - the high affinity receptor seems to be coupled to inotropic effects, the low affinity receptor is linked to inhibition of (Na.+K.)-ATPase.
小卷发
发表于 2025-3-31 23:26:26
Subclassification of cardiac glycoside receptors,u discovered Na,K-ATPase and since, the mechanism of Na and K transport has been extensively investigated. Several physiological processes are coupled to the Na,K-pump, the identification of this coupling has been demonstrated by blockade of the pump by large doses of cardiac glycosides.