Pert敏捷 发表于 2025-3-28 18:26:51
Nonradioactive Analysis of Biomoleculesh the increase in the intracellular Na. concentration. It is suppressed in Na. free medium or when Na. is replaced by Li. suggesting that the increase is due to the indirect activation of the Na./Ca. exchange system in the plasma membrane. Dose-response curves for the inotropic effects of ouabain on玉米 发表于 2025-3-28 20:12:23
Nonradioactive Analysis of Biomoleculeseems to correlate with the inotropic action, whereas the low affinity ouabain binding is more related to NaK-ATPase inhibition..To further discriminate the two cardiac glycoside binding sites operative in guinea pig heart muscle, erythrosin B, shown to be an inhibitor of the high affinity ouabain biincision 发表于 2025-3-29 00:02:13
http://reply.papertrans.cn/23/2218/221777/221777_43.pngNutrient 发表于 2025-3-29 05:39:42
Contractility of isolated bovine ventricular myocytes is enhanced by intracellular injection of car轻弹 发表于 2025-3-29 09:09:01
The electrogenic Na-K pump current and actions of the cardiac glycosides,intangibility 发表于 2025-3-29 14:33:01
http://reply.papertrans.cn/23/2218/221777/221777_46.pngMonocle 发表于 2025-3-29 17:49:41
Cardiac glycosides with different effects in the heart,Electrolysis 发表于 2025-3-29 21:14:18
Cardiac glycoside receptors and positive inotropy Evidence for more than one receptor?, the latter 3. would cause an increase of intracellular Ca., which in turn would 4. stimulate the contractile proteins to a larger extent than before addition of the drugs. This hypothesis seemed to explain the increase in force of contraction rather well and also the clinically important arrhythmia有帮助 发表于 2025-3-30 02:41:35
Binding sites for ouabain in human and rat erythrocytes and in rat heart cells,s only the bond between C-2 and C-3 of the rhamnose without affecting the steroid moiety. The periodate oxidation provided additional information for assigning a distorted chair conformation or a transient boat conformation for rhamnose in ouabain. It was also established by .H NMR spectroscopy that容易做 发表于 2025-3-30 05:14:19
Cardiac glycosides and intracellular Na+, K+, Ca2+,hythmias are present. The increase of intracellular free and bound calcium, which manifests itself functionally as contracture, is believed to be caused at least by two mechanisms: a stimulation of the Na-Ca-exchange and an inhibition of the specific Ca.-activated ATPase in the plasma membrane catal