ALB
发表于 2025-3-28 17:45:22
Neuroinflammation in Huntington’s Disease agent to the covalent binary complex formed between topoisomerase I (TOP-I) and DNA (Fig. 2) (.). Although the equilibrium between free enzyme and the enzyme-DNA binary complex normally lies far toward free enzyme and DNA, in the presence of CPT, the equilibrium is rapidly displaced toward ternary
considerable
发表于 2025-3-28 22:27:58
Golam M. Khandaker,Urs Meyer,Peter B. Jones The sodium salt of CPT was found to be clinically active, but its use was discontinued in the 1970s because of severe side effects and lack of understanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-solub
OVER
发表于 2025-3-29 01:17:49
https://doi.org/10.1007/978-3-662-05426-0changes in DNA topology are important during cellular processes involving DNA, including DNA replication, recombination, transcription, and chromosome condensation (.–.). The monomeric Top1 enzyme, encoded by the . gene, binds to duplex DNA and catalyzes the transient cleavage and relegation of a si
Incise
发表于 2025-3-29 03:47:57
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旋转一周
发表于 2025-3-29 11:17:19
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Myosin
发表于 2025-3-29 13:16:38
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esculent
发表于 2025-3-29 19:36:26
Sleep Immune Cross Talk and Insomniaty against human colorectal cancer xenografts (.). This led to an extensive drug development program for 9-AC initially under the guidance of the National Cancer Institute, and later in cooperation with pharmaceutical industry sponsors. However, despite this impressive preclinical activity, 9-AC has
最初
发表于 2025-3-29 19:56:41
Sleep Immune Cross Talk and Insomniaparent compound, CPT, derived from the bark of the . tree, was introduced into clinical trials in the late 1970s. Because of its poor water solubility, CPT was formulated in sodium bicarbonate, which opened the 20(S) lactone ring and caused significant toxicity and inconsistent clinical activity. He
憎恶
发表于 2025-3-30 02:58:41
Il Bin Kim,Seon-Cheol Park,Yong-Ku Kim of the Chinese shrub .. The mechanism of action of camptothecin has been covered in other chapters of this book and need not be revisited here. However, it is pertinent to point out that CPT-11 itself is only a very weak stabilizer of the cleavable complex formed between DNA and topoisomerase I (TO
迫击炮
发表于 2025-3-30 05:08:27
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