Liability
发表于 2025-3-25 04:22:43
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palliate
发表于 2025-3-25 09:13:24
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符合规定
发表于 2025-3-25 13:11:14
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GRAZE
发表于 2025-3-25 18:07:14
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先锋派
发表于 2025-3-25 23:24:27
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spinal-stenosis
发表于 2025-3-26 02:23:11
Clinical Experience With 9-Aminocamptothecinical research. Thus a careful review of the early clinical and pharmacological trials of 9-AC may help us to understand why 9-AC has not shown more meaningful antitumor activity and may also provide important lessons for the future drug development of novel camptothecins and other topoisomerase I (TOP-I) targeting agents.
Sleep-Paralysis
发表于 2025-3-26 07:43:18
Irinotecan–.). In turn, SN-38 can be conjugated to SN-38 β-glucuronide (.,.). CPT-11 is also metabolized to an aminopentanocarboxylic (APC), metabolite (. Fig. 1), and other minor, mostly inactive, products by cytochrome P450 3A4/5 (.–.).
任命
发表于 2025-3-26 11:29:28
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整体
发表于 2025-3-26 15:56:49
Neuroinflammation in Alzheimer’s Diseaseication reaction (.). The rate of relegation is normally much faster than is the rate of cleavage (.). This ensures that the steady state concentration of the covalent 3′-phosphotyrosyl TOP-I-DNA complex is extremely low. Several DNA lesions and drugs, however, have been shown to stabilize the coval
急性
发表于 2025-3-26 19:51:26
https://doi.org/10.1007/978-3-662-05426-0OH DNA end attacks the phosphotyrosyl bond to restore the phosphodiester backbone bond and liberate the enzyme. The formation of a covalent Top1p-DNA complex is the hallmark of topoisomerase-catalyzed reactions and acts to conserve the energy of the cleaved DNA bond such that the concerted nicking a