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The Organelles II: Endoplasmic Reticulum and its Overloadfunctioning is impaired in multiple ways. These include disturbances of ER calcium homeostasis, impairment of ERAD and UPR, and insufficient proteasome functioning which triggers secondary ER dysfunction. Therapeutic interventions designed to suppress the pathological process culminating in neuronal巩固 发表于 2025-3-22 12:00:24
Transcriptional Dysfunctions as Pathogenic Mechanism of Neurodegenerative Diseases protein diversity and determine the subcellular location, molecular interactions, or function of proteins. Neuron-specific proteins involved in RNA splicing and metabolism are affected in several neurological disorders. Defects in RNA processing proteins, such as SMN protein, may lead to the Spinalmalign 发表于 2025-3-22 16:58:41
Formation of Radicalsn’s disease increased levels of biomarkers of oxidative and nitrosative stress have been identified in the brain. Some of which such as hydroxyalkenals and isoprostanes may even gain diagnostic value for the determination of the degree of neurodegeneration. However, scientific efforts have to be conHyperalgesia 发表于 2025-3-22 17:16:08
Microglia and the Cerebral Defence System or disturbances in the CNS homeostasis. Deregulated or dysfunctional microglia can, on the other hand, be critical or at least instrumental in a harmful way. Excessive and chronic reaction of microglia can then fuel destructive cascades upon trauma or during inflammatory and neurodegenerative proce确定方向 发表于 2025-3-23 00:28:33
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