Gum-Disease
发表于 2025-3-23 12:37:04
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脆弱带来
发表于 2025-3-23 16:53:04
A Role for Iron in the Degradation of DNA by BleomycinrsS. as a copper chelate, it is used clinically as a metal-free preparation. Studies with bleomycin have suggested that its cytotoxic properties are related to effects of the compound on the physical integrity of DNA in cells. In cultures of bacterial or eukaryotic cells, a major effect of bleomycin
Recess
发表于 2025-3-23 21:47:03
Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNA by Bleomycinre effective against squamous cell carcinoma, Hodgkin’s disease, and malignant lymphoma and are particularly valuable since they show no immunosuppression.. The mode of action has attracted a great deal of attention but the molecular mechanism of action is by no means clear. BLM shows interference w
省略
发表于 2025-3-23 22:49:02
Interaction of Bleomycin with DNAbited by simultaneous addition of DNA from other species (protection by competitive binding) but not by the addition of RNA. Based on the protective effect of the added DNA, the preferred DNA structure for interaction with bleomycin was determined. The results indicate that bleomycin binds preferent
摇曳
发表于 2025-3-24 04:06:58
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爱国者
发表于 2025-3-24 08:18:30
Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNAezawa ... It has been established that the drug causes the release of free bases, ruptures the phosphodiester backbone, and damages the deoxyribose moiety of DNA. There are no detectable damaging effects on RNA, nor does the drug alter the ability of mRNA to direct cell-free protein synthesis. For a
Nonthreatening
发表于 2025-3-24 13:19:36
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含糊
发表于 2025-3-24 16:39:22
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Detoxification
发表于 2025-3-24 20:02:23
https://doi.org/10.1007/978-1-4612-6191-9Bleomycin; Pyrimidine; biochemistry; biology; cancer; cell; chemistry; synthesis
高脚酒杯
发表于 2025-3-25 02:12:55
978-1-4612-6193-3Springer-Verlag New York Inc. 1979