Dna262
发表于 2025-3-23 10:27:34
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啮齿动物
发表于 2025-3-23 15:37:32
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inchoate
发表于 2025-3-23 19:49:12
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Expiration
发表于 2025-3-23 23:06:37
Positron Emission Tomography (PET) Imaging Biomarkers in Huntington’s Diseases in pwHD have been performed, most of which have claimed subclinical biomarker (e.g. phosphodiesterase 10a, dopaminergic receptors) impairment before the appearance of overt HD symptoms. This finding stresses the importance of early detection and potential intervention, decades before age of onset.
确定无疑
发表于 2025-3-24 04:09:35
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光亮
发表于 2025-3-24 08:07:14
Proteomics in Huntington’s Disease Biomarker Discovery tissues and models, several known and novel candidates emerged as consistently affected in HD. Based on MS-based HD studies, we propose the monitoring of existing markers mutant Huntingtin (mHTT) and neurofilament light polypeptide (NfL), together with novel candidate markers, such as proenkephalin
cumulative
发表于 2025-3-24 12:21:28
Microbiome and Metabolomic Biomarkers for Huntington’s Diseaseate biomarkers, including components of the gut microbiome and circulating metabolites. Changes to gut microbiome composition can be quantified using a variety of sequencing methods. This includes polymerase chain reaction, 16S rRNA sequencing, and metagenomic analysis. Metabolomic techniques can be
Opponent
发表于 2025-3-24 16:05:06
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古代
发表于 2025-3-24 21:13:25
TAR DNA-Binding Protein 43 as a Potential Biomarker for Huntington’s DiseaseHowever, several case reports of individuals with the HTT mutation and ALS-like syndrome suggest potential interactions and involvement of TDP-43 in the pathophysiology and phenotype of some individuals with HD. Investigations into other PolyQ diseases, such as Spinocerebellar Ataxias, have provided
懒鬼才会衰弱
发表于 2025-3-25 02:10:59
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