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rcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a 978-1-4613-4126-0978-1-4613-4124-6藐视 发表于 2025-3-30 20:50:04
The Concept of Reactive Electrophilic Metabolites in Chemical Carcinogenesis: Recent Results with Arractions .. Such interactions may pose carcinogenic, mutagenic, teratogenic, allergenic, necrogenic, and possibly other hazards that must be weighed against the benefits provided by each drug in this category.RAG 发表于 2025-3-31 04:23:08
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https://doi.org/10.1007/978-3-658-22972-6ractions .. Such interactions may pose carcinogenic, mutagenic, teratogenic, allergenic, necrogenic, and possibly other hazards that must be weighed against the benefits provided by each drug in this category.adequate-intake 发表于 2025-3-31 11:14:12
Klimawirksame Kennzahlen Band IIhus be an important factor in the heterogeneity of individuals to carcinogen susceptibility. Thus it is important to have methods to determine the profiles of these enzyme activities in individuals so that their relationship to carcinogenesis can be understood. In this chapter we present various met一瞥 发表于 2025-3-31 17:15:45
Introduction to the Concept of Reactive Intermediatesresponses has been developing since the beginning of this century. In the last 10 years or so, it has become evident that chemically reactive metabolites may be the cause of serious forms of toxicity including cellular necrosis, mutagenesis, carcinogenesis, teratogenesis, hypersensitivity, and blood厌倦吗你 发表于 2025-3-31 21:33:41
The Concept of Reactive Electrophilic Metabolites in Chemical Carcinogenesis: Recent Results with Arth tissue macromolecules (1,2), and a large literature now exists on this subject and its relevance to carcinogenesis by these agents (3–5). Considering the great structural heterogeneity of chemical carcinogens (5–8) and of drugs in general, it is not surprising that at high dosage levels a few dru织物 发表于 2025-3-31 21:45:50
Kinetics of Reactive Metabolites and Covalent Binding , and ,t with a number of substances in tissues and thereby cause changes which result in various toxicites including cancer, mutagenesis, cellular necrosis, immunological reactions, blood dyscrasias, and fetal damage (1–11). Because of the seriousness of these toxicities, my laboratory has been engaged in