恳求 发表于 2025-3-21 17:54:20
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Mechanism of Microsomal Monooxygenases and Drug Toxicityug may cause an activation of another drug which could result in cell damage or even cancer. Therefore, the booming research in drug metabolism during the last two decades has also provided the knowledge for our understanding of drug toxicity.Constitution 发表于 2025-3-22 03:18:51
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https://doi.org/10.1007/978-3-658-19515-1e intermediates. These epoxide intermediates in turn undergo enzymatic reactions mediated by epoxide hydrase or glutathione-.-epoxide transferase, or are non-enzymatically converted to various hydroxylated products. Epoxides also react irreversibly with cellular components (2).alleviate 发表于 2025-3-23 01:12:24
Introduction to the Concept of Reactive Intermediatestes may be the cause of serious forms of toxicity including cellular necrosis, mutagenesis, carcinogenesis, teratogenesis, hypersensitivity, and blood disorders such as hemolytic anemia, blood dyscrasias, and methemoglobinemia.mercenary 发表于 2025-3-23 01:34:01
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Discussiona fundamental component of the fetal liver. In contrast, the lack of P450 in the fetus of common laboratory animals suggests that they may not require the ability to metabolize steroids during fetal life.