Fuctionary 发表于 2025-3-21 18:50:46
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Functional Characterization of Human Genes from Exon Expression and RNA Interference Results,involved genes and proteins are crucial for modeling and understanding such systems. To interrogate the various cellular processes, high-throughput techniques such as the Affymetrix Exon Array or RNA interference (RNAi) screens are powerful experimental approaches for functional genomics. However, t干旱 发表于 2025-3-22 05:19:34
,Barcode Sequencing for Understanding Drug–Gene Interactions, describe in detail a protocol for Barcode analysis by sequencing (Bar-seq) to assess pooled competitive growth of individually barcoded yeast deletion mutants. This protocol has been optimized on two sequencing platforms: Illumina’s Genome Analyzer IIx/HiSeq2000 and Life Technologies SOLiD3/5500. I我正派 发表于 2025-3-22 12:06:49
High-Throughput Sequencing of the Methylome Using Two-Base Encoding,ells. Changes in the methylation patterns have been shown to be associated with the development of cancer, growth, neurodevelopmental, and endocrine disorders (Laird PW, Nat Rev Genet 11:191–203, 2010; Tost J, Mol Biotechnol 44:71–81, 2010; Zuo T et al., Epigenomics 1:331–345, 2009). Thus, studyingAWE 发表于 2025-3-22 15:07:03
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Mapping Between Databases of Compounds and Protein Targets,They join the expanding universes of cheminformatics via chemical structures on the one hand and bioinformatics via sequences on the other. However, it is difficult to assess the relative utility of databases without the explicit comparison of content. We have exemplified an approach to this by comp伪善 发表于 2025-3-23 03:00:01
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