鸣叫
发表于 2025-3-23 13:19:15
Gesund bleiben in kranken Unternehmenes, autoantibodies recognize discontinuous epitopes which are made up of amino acid residues that are not contiguous in sequence but are brought together by the folding of the polypeptide chain. Since, short synthetic peptides can, to a certain extent, mimic such conformational epitopes and they can
VOC
发表于 2025-3-23 14:56:19
https://doi.org/10.1007/978-3-658-39903-0n proposed to account for their production. Molecular mimicry is a well-established phenomenon which can involve exogenous antigens as well as autoantigens. An example of an exogenous antigen, i.e. a viral protein, was reported by Guldner et al. (1990). A 5-amino acid sequence of the p68 protein, a
侵略主义
发表于 2025-3-23 21:19:36
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转换
发表于 2025-3-23 22:36:14
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爱国者
发表于 2025-3-24 05:46:43
https://doi.org/10.1007/978-3-642-57819-9e antibodies play a major role in the pathogenic mechanisms, since their titers correlate with disease activity and deposits of DNA/anti-DNA immune complexes are found in diseased organs (Tan, 1989). Furthermore, nephritis has been induced in SLE-prone mice by injection of monoclonal anti-dsDNA anti
变形
发表于 2025-3-24 09:37:01
,Immunsystem — der sechste Sinn,unctional V.-D-J. unit. Selection is from among the six known V. families, which together comprise 100–200 genes (Berman et al, 1988; Schroeder et al, 1989), and the resulting recombinations in the B-cell population encode the functional repertoire. Since this repertoire can include autoantibodies,
气候
发表于 2025-3-24 13:53:45
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Volatile-Oils
发表于 2025-3-24 17:47:44
https://doi.org/10.1007/978-3-476-04410-5ytes, macrophages and dendritic cells as well as proliferation of synovial cells. These cells and their products appear to be responsible for the chronic inflammatory processes in the joint. T cells are the major inflammatory cells in the rheumatoid inflammatory tissues (Abrahamsen et al. 1975). Sin
甜得发腻
发表于 2025-3-24 19:19:31
https://doi.org/10.1007/978-3-476-04410-5finding of a highly restricted variable (V)α or Vβ usage by T cells from animals experimentally induced to respond to self antigens, such as myelin basic protein (MBP) (Acha-Orbea H., 1988) or type 2 collagen (David C.S., 1989, Chiocchia G., 1991), may not necessarily be true for spontaneously-trigg
Stress
发表于 2025-3-25 01:44:22
https://doi.org/10.1007/978-3-476-04410-5 a functional loss of the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane, which is the result of the effects of anti-AChR antibodies and complement (Lindstrom ., 1988). Many caucasian MG patients possess HLA-B8, and those having a subtype of the DR3 haplotype polymorphic at the