蚊子
发表于 2025-3-30 11:15:05
Tomudex,er drug that owes its cytotoxicity to inhibition of the enzyme thymidylate synthase (TS). TS catalyzes the reductive methylation of deoxyuridylate monophosphate (dUMP) to thymidylate (TMP), the rate-limiting step in the . synthesis of thymidine triphosphate (TTP), the only nucleotide specific for DN
不持续就爆
发表于 2025-3-30 16:05:20
Preclinical Pharmacology Studies and the Clinical Development of a Novel Multitargeted Antifolate,agents for the management of neoplastic diseases. However, it was only in the last 10–15 yr, because of the rapid advances of medicinal chemistry, X-ray protein crystallography, molecular biology, pharmacology, and clinical medicine, that a significant number of new generation antifolates were brou
FRAX-tool
发表于 2025-3-30 18:12:40
GW1843,te moieties in vivo. However, unlike some other TS inhibitors and other antifolates, the TS inhibition constant and noncompetitive mode of inhibition is unaffected by polyglutamation. The compound is readily transported on the reduced folate carrier, and accumulates in cells. The main cellular metab
确定方向
发表于 2025-3-31 00:33:19
Preclinical and Clinical Studies with the Novel Thymidylate Synthase Inhibitor Nolatrexed Dihydrochriority to evaluate drugs that may possess either greater efficacy or activity in tumors with intrinsic or acquired resistance to established treatment. Nolatrexed dihydrochloride (Thymitaq.) is a novel folate-based inhibitor of thymidylate synthase (TS). TS is the rate-limiting enzyme in the . bios
臆断
发表于 2025-3-31 02:20:05
ZD9331,nce DNA synthesis, has been achieved with a range of quinazoline analogs of folic acid, including CB3717 (.–.) and its non-nephrotoxic successor, Tomudex. (ZD1694, raltitrexed) (.–.). The latter compound has recently been introduced in a number of counties for the treatment of advanced colorectal ca
catagen
发表于 2025-3-31 05:33:03
Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors ycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme in this pathway, might have utility in the treatment of cancer. In 1987, clinical investigations were initiated with lometrexol (6R-dideazatetrahydrofolic acid, 6R-DDATHF), a novel “tight-binding” inhibitor of GARF
Memorial
发表于 2025-3-31 12:00:18
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抗原
发表于 2025-3-31 13:46:56
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继而发生
发表于 2025-3-31 19:40:01
Folates as Chemotherapeutic Modulators,in hematopoietic cells and intestinal mucosa, with lesser effects on kidney, liver, and the central nervous system (.). An accepted strategy to overcome these toxicities is the supplementation of folates as rescue agents (.–.). In this context, the use of high doses of methotrexate (MTX) with leucov
Antigen
发表于 2025-4-1 00:36:21
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