adjacent
发表于 2025-3-26 23:16:39
C. Guillén,M. C. Romero,I. Galindo 5´-thienyl-dideazatetrahydrofolic acid), which is more potent than lometrexol and has greater antitumor efficacy in vivo (2). Biochemical and pharmacological differences between LY309887 and lometrexol with respect to potency to inhibit GARFT, differential transport and storage in liver, and polygl
BUCK
发表于 2025-3-27 05:12:28
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详细目录
发表于 2025-3-27 08:40:30
Javier Dóniz-Páez,Rafael Becerra-Ramírezreductase (DHFR) (.). More recently, folate analogs were synthesized that could target other key enzymes in folate metabolism, including thymidylate synthase (TS) (., .) glycinamide ribonucleotide transformylase (GARTFase) (., .) and folylpolyglutamate synthetase (FPGS) (.). A number of these novel
必死
发表于 2025-3-27 13:09:08
https://doi.org/10.1007/978-3-031-07289-5ity in several epithelial malignancies (.–.). The rational use of folates as modulators of toxicity or antitumor activity requires an integral understanding of their biochemistry, pharmacokinetics, and pharmacodynamics.
PRO
发表于 2025-3-27 17:33:26
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关节炎
发表于 2025-3-27 21:18:28
Folate Biochemistry in Relation to Antifolate Selectivity,r et al. . in 1948. This work depended on knowledge generated at the American Cyanamid Company, Pearl River, NY, on the structure of folic acid and the chemical synthesis of analogs in addition to the insightful clinical observations of the Farber group .. This work was done before the role of tetra
legitimate
发表于 2025-3-27 23:02:41
Raltitrexed (TomudexTM), a Highly Polyglutamatable Antifolate Thymidylate Synthase Inhibitor,f knowledge for the development of the antifolate thymidylate synthase (TS) inhibitors over the last 20 yr (. Chapter 1). For example, it was shown that the cytotoxicity induced by the indirect inhibition of TS by MTX may be antagonized by its inhibitory effects on . purine synthesis .. The antipuri
有其法作用
发表于 2025-3-28 02:09:19
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泥沼
发表于 2025-3-28 07:19:23
Preclinical and Clinical Studies with the Novel Thymidylate Synthase Inhibitor Nolatrexed DihydrochThe folate-based cytotoxic agents are more likely, when compared with their pyrimidine-based counterparts, to have a unique locus of action, not be incorporated into nucleic acids, and not be susceptible to catabolic degradation. The first clinically evaluable folate-based TS inhibitor was CB3717. T
Hearten
发表于 2025-3-28 14:01:30
ZD9331,f more recent interest has been the development of water-soluble acidic, quinazoline-based TS inhibitors that lack FPGS substrate activity but retain high affmity for the RFC. Work from the group of F. Sirotnak (.) has provided evidence that compounds with favorable kinetic parameters for the RFC ma