Stable-Angina
发表于 2025-3-25 03:39:18
Calcium Channel Antagonists in Mood Disorders,ressant, in 1956, numerous compounds have been developed and others have faded from the market. In fact, until the advent of the selective serotonin reuptake inhibitors (SSRIs) in the late 1980s, there had been no clear advances in the pharmacotherapy of mood disorders. Despite the fact that SSRIs o
使害羞
发表于 2025-3-25 09:03:20
Functional NMDA Antagonists,rugs with no apparent structural relationship, but possessing similar clinical efficacies. Despite the similarity in therapeutic outcome, in vitro studies suggest that each class of antidepressant drugs predominantly modulates different neurotransmitters via either enzyme or reuptake inhibition. The
MOAN
发表于 2025-3-25 14:52:37
Is an Adaptation of NMDA Receptors an Obligatory Step in Antidepressant Action?,(e g, imipramine and mianserin, respectively) to nonfused polyaromatic molecules (e.g., zimelidine) (Fig. 1). Most antidepressants have well-documented effects on either biogenic amine reuptake or metabolism, and it is these neurochemical properties (e.g., blockade of serotonin reuptake, inhibition
Anticoagulants
发表于 2025-3-25 19:24:02
NMDA Receptors and Affective Disorders,7). Functional antagonists of the NMDA receptor complex, including a competitive NMDA antagonist (2-amino-7-phosphonoheptanoic acid ., a glycine partial agonist (1-aminocyclopropanecarboxylic acid ., and a use-dependent channel antagonist (dizocilpine ., are as efficacious as tricyclic
修饰语
发表于 2025-3-25 19:58:57
http://reply.papertrans.cn/16/1586/158532/158532_25.png
积习已深
发表于 2025-3-26 04:02:46
http://reply.papertrans.cn/16/1586/158532/158532_26.png
neuron
发表于 2025-3-26 08:21:16
http://reply.papertrans.cn/16/1586/158532/158532_27.png
很是迷惑
发表于 2025-3-26 08:39:24
Animal Models to Detect Antidepressants,rom the inadequacies of the therapies that are currently available. The traditional (first-generation) antidepressants suffer from three major drawbacks: They have unacceptable side effects; their efficacy is low; and their therapeutic effects develop slowly, typically requiring 3–4 wk of treatment
NIP
发表于 2025-3-26 16:13:38
Molecular Strategies to Novel Antidepressant Discovery, one might legitimately ask, “Why do we need new antidepressant agents?” Indeed, the SSRIs and their less-selective predecessors, the tricyclic antidepressants and monoamine oxidase inhibitors, are effective in approx 65–70% of patients when systematically investigated in “double-blind” placebo-cont
Limited
发表于 2025-3-26 20:19:01
http://reply.papertrans.cn/16/1586/158532/158532_30.png