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A Role for CREB in Antidepressant Action,ntracellular cascades control virtually every aspect of neuronal function, including the regulation of gene transcription. It is reasonable to hypothesize that adaptations of these intracellular sites are responsible for the therapeutic action of antidepressant treatments .–..致命 发表于 2025-3-24 13:39:41
Strategies to Optimize the Antidepressant Action of Selective Serotonin Reuptake Inhibitors,any brain neuronal systems, the serotonin (5-hydroxytryptamine, 5-HT) system is the most common neurobiological target for such treatments. Tricyclic antidepressants (TCAs) act on 5-HT and noradrenergic (NE) neurons by inhibiting, with different potencies, transmitter reuptake ., and monoamine (MAO)匍匐前进 发表于 2025-3-24 14:55:13
,Antidepressant Properties of Specific Serotonin—Noradrenaline Reuptake Inhibitors,antidepressant starts to produce its therapeutic effect in less than 2–3 wk. Although considerable progress has been made in improving the tolerability of antidepressant drugs, the tricyclic antidepressants (TCAs), developed in the early 1960s, are still the “gold standard” for antidepressant efficahermetic 发表于 2025-3-24 19:22:59
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Reversible Inhibitors of Monoamine Oxidase A (RIMAs),hese are considerably safer than the older, nonselective irreversible monoamine oxidase inhibitors (MAOIs), in that they have much less interaction with tyramine and certain drugs. Many trials have shown them to be of benefit in depression, and there is room for more variants of this type of drug to