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Molecular Mechanisms of Isotype Switching to IgEwitch to a particular isotype, a B-cell needs to receive two signals: signal 1 is cytokine-dependent, results in the activation of transcription at a specific region of the Ig locus, and determines isotype specificity. Signal 2 activates the recombination machinery, and leads to DNA switch recombination.incubus 发表于 2025-3-22 13:12:26
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