联邦
发表于 2025-3-25 04:18:11
Explaining Medical Model Exceptions (ADT) represents a good therapeutic tool for the treatment of PCa patients, but after an initial period of remission, the disease progresses towards an androgen-independent (AI) state. While in androgen-dependent (AD) stage the roles of androgens and their receptor (AR) are fully described inAI, th
小平面
发表于 2025-3-25 10:16:12
Studies in Computational Intelligence-like growth factors (IGF) I and II plays a role in the development and progression of a variety of malignancies, including prostate cancer. Recent studies indicate that membrane-initiated effects of both androgens and estrogens provide a non-mutational mechanism for marked IGF-IR upregulation in pr
最高点
发表于 2025-3-25 11:44:38
S Spelmen Vimalraj,Porkodi Rajendranan exquisite sensitivity to androgen deprivation therapy and is the most endocrine-sensitive solid neoplasm, although the disease may eventually progress to the castration-resistant status (CRPC). However, recent evidence was provided that the cancer progression at the CRPC stage is often mediated b
行为
发表于 2025-3-25 17:30:44
https://doi.org/10.1007/978-3-642-30621-1have provided deep insights into NR function but, due to their nature as single endpoint assays derived from pooled cell populations and tissues, these approaches are intrinsically unable to address important mechanistic considerations linked to cellular heterogeneity. Androgen receptor (AR) and est
Insatiable
发表于 2025-3-25 22:26:25
Mattia Broilo,Francesco G. B. De Natalelter gene expression. These processes typically take at least 30 to 60 min for an increase in mRNA expression to be observed. In contrast, other regulatory actions of steroid hormones such as increases in activity of mitogen activated protein kinases are manifested within seconds to a few minutes an
手榴弹
发表于 2025-3-26 04:05:43
http://reply.papertrans.cn/15/1496/149543/149543_26.png
孵卵器
发表于 2025-3-26 07:06:03
http://reply.papertrans.cn/15/1496/149543/149543_27.png
细颈瓶
发表于 2025-3-26 09:45:29
http://image.papertrans.cn/a/image/149543.jpg
Middle-Ear
发表于 2025-3-26 13:41:02
Cosmin Danut Bocaniala,José Sá da Costasic model of steroid hormone action as restricted to classic cell types rather than valid for all steroid target cells. Cross talk between membrane receptors and nuclear steroid receptors regulates nuclear steroid receptor action. An additional cross talk occurring between membrane receptors and ext
Fibrinogen
发表于 2025-3-26 16:49:15
http://reply.papertrans.cn/15/1496/149543/149543_30.png