onlooker
发表于 2025-3-28 16:59:48
Sylvia Hubner-Benzor Parkinson’s disease and dementia with Lewy bodies using . CSF. Here we provide detailed protocols for our 3R tau and αSyn RT-QuIC assays and refer the reader to published up-to-date protocols for prion RT-QuIC assays (Orru et al. Methods Mol Biol 1658:185–203, 2017; Schmitz et al. Nat Protoc 11:2233–2242, 2016).
令人悲伤
发表于 2025-3-28 21:38:55
Sylvia Hubner-Benznatural proteins, protein sequences appear to have evolved to reduce their propensities to aggregate. One of the strategies by which proteins have achieved this end has been to modulate their aggregation potential by playing with these factors.
panorama
发表于 2025-3-29 01:42:06
asis for SOD1-linked ALS, with a strong emphasis on the biophysical and structural properties of the enzyme. Enhanced understanding of the structural basis for pathogenic SOD1 misfolding and self-association is likely to be a prerequisite for the development of therapeutic avenues of this progressive neurodegenerative disease.
巧思
发表于 2025-3-29 06:34:55
and unliganded IgM. Then, when IgM binds to a cell surface, this dynamic equilibrium would be much shifted in favor of the forms possessing the sites which interact with complement, and in consequence the rate would be greatly enhanced. This shift in the dynamic equilibrium of protein structures would then represent the conformational change.
badinage
发表于 2025-3-29 08:12:41
Sylvia Hubner-Benzg, or (3) transferred from the E2 via a thioester bond to an active site cysteine residue in one of a growing family of E3 ubiquitin ligases, which then conjugate ubiquitin to specific target proteins.
flourish
发表于 2025-3-29 12:08:26
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Pathogen
发表于 2025-3-29 17:47:39
Sylvia Hubner-Benzble signal levels are discussed and compared with a wide variety of recent experiments carried out at XFEL, synchrotron, and even laboratory sources, to discuss the capabilities of these new approaches and give some perspectives on their further development.
听觉
发表于 2025-3-29 22:25:42
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squander
发表于 2025-3-30 03:28:28
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好忠告人
发表于 2025-3-30 04:58:33
Sylvia Hubner-Benztraditional lab scale. The agreement in the data is indeed very significant (regression coefficient 0.93). We think that this protocol will be of significant value to those involved in performing high-throughput process development of process chromatography.