Ornament
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978-3-531-15197-7VS Verlag für Sozialwissenschaften | Springer Fachmedien Wiesbaden GmbH, Wiesbaden 2008
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Front Matterm is impaired for many substrates. This may be the reason for a higher incidence of adverse drug reactions in the elderly. We studied the influence of age on the hepatic elimination of two low clearance model-substrates of the oxidative metabolism, hexobarbital (cytochrome P 450) and caffeine (cytoc
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herapeutic effect together with the progress in the analytical procedures to determine these drugs in body fluids have strongly stimulated the development of clinical pharmacokinetics. The availability of drug concentrations in body fluids has improved the possibility of monitoring patients on chron
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