代理人
发表于 2025-3-25 07:23:35
Evolution and Function of Vitamin De and bone in order to maintain calcium homeostasis. The VDR is also present in a wide variety of other tissues. 1,25(OH).D.interacts with these receptors to have a multitude of important physiological effects. In addition, it is now recognized that many tissues, including colon, breast and prostate
过分
发表于 2025-3-25 10:52:15
Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural ainteractions of the ligand-binding domain (LBD) of the VDRwith coactivator (CoA), corepressor (CoR) and other nuclear proteins. Mostanalogs have been identified as agonists, a few as antagonists (ZK159222 and TEI-9647) and only Gemini and some of its variations as nonagonists. The positioning of hel
Irrigate
发表于 2025-3-25 12:11:25
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scotoma
发表于 2025-3-25 19:25:57
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Asparagus
发表于 2025-3-26 00:04:12
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安心地散步
发表于 2025-3-26 04:11:45
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indicate
发表于 2025-3-26 07:08:13
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使害羞
发表于 2025-3-26 11:03:05
Extrarenal Sites of Calcitriol Synthesis:The Particular Role of the Skin at least 1α- OH-, 25OH- and 24OHase activity, which is necessary for enzymatic conversion of D.to 1α,25(OH).D., and the 24OHase activity for initiation of catabolism of 1α,25(OH).D.to more polar metabolites. Thus, the skin is apparently the only extrarenal tissue where the complete UVB-induced path
盲信者
发表于 2025-3-26 14:43:08
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CHIP
发表于 2025-3-26 19:18:44
Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolismtively inhibit CYP24, but not hormone synthesis by the related CYP27B. Using primary human keratinocyte cultures as the source of CYP24 and CYP27, we discovered some 50 inhibitors of CYP24 with IC50 values in the nanomole range and selectivities up to 60-fold. As the first representative of selectiv