STELL
发表于 2025-3-25 06:18:33
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出处
发表于 2025-3-25 10:16:11
Structure and Activation Mechanism of GPCRs, by extracellular stimuli, GPCRs trigger cytoplasmic signalling pathways through intracellular partners such as G-proteins and arrestins. This chapter provides a general overview of the molecular mechanisms of GPCR activation gleaned from crystal structures, biophysical experiments, and computationa
玷污
发表于 2025-3-25 14:32:51
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保全
发表于 2025-3-25 16:45:15
Integration on Ligand and Structure Based Approaches in GPCRs,maceutical importance. Modification of the cell-specific signaling and functioning of the GPCRs provides an excellent opportunity for drug design activities. In view of the diverse and complex nature of GPCR signaling, the proper understanding of receptor structure is essential to illustrate their e
做作
发表于 2025-3-25 21:55:27
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Brittle
发表于 2025-3-26 00:38:56
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古代
发表于 2025-3-26 06:15:26
Structure and Function Studies of GPCRs by Site-Specific Incorporation of Unnatural Amino Acids,nal changes, for the screening of ligand–protein and protein–protein interactions, and as alternatives to conventional labeling approaches for the site-specific labeling of GPCRs with spectroscopy probes. Interactome mapping among GPCRs, their ligands, and interactive proteins discovered using genet
Mri485
发表于 2025-3-26 11:20:51
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HARD
发表于 2025-3-26 14:49:50
Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Liganeptors: ligand-gated ion channels and G-protein-coupled receptors (GPCRs), named ionotropic and metabotropic glutamate receptors (mGluRs), respectively. The mGluR family consists of eight subtypes which are responsible for glutamate neuromodulatory actions throughout the CNS. These receptors are com
任意
发表于 2025-3-26 17:55:33
Book 2019al basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the impor