Systole 发表于 2025-3-21 19:38:17
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Josef Wankestem called RILES, standing for RNAi-inducible expression system, which relies on an engineered regulatable expression system, to switch on the expression of the luciferase gene when the targeted miRNA is expressed in cells. We demonstrated that RILES is a specific, sensitive, and robust method to d正式演说 发表于 2025-3-22 09:34:45
Josef Wankeon. In many eukaryotes, one of the major roles for RNAi-related mechanisms is silencing transposons, and DNA elimination in . is also believed to have evolved as a transposon defense by removing transposon-related sequences from the somatic genome. Because DNA elimination is achieved by the coordinaApoptosis 发表于 2025-3-22 16:45:53
Josef Wankes governed by them. We also present our current understanding on these post-transcriptional networks in the context other cellular networks. We finally argue that such developments would not only allow us to gain a deeper understanding of regulation at a level that has been under-appreciated over thPalpate 发表于 2025-3-22 18:15:53
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Josef Wanke histone code, silent state chromatin marks, and ultimately heterochromatization of the targeted gene. The observation that siRNA-directed TGS is operative via epigenetic modifications suggests that similar to plants, and ., human genes may also be able to be silenced more permanently or for longerfigure 发表于 2025-3-23 04:58:40
Josef Wankepts leading to decreased gene expression resulted in a paradigm shift in the field of molecular biology. Transgene silencing was first discovered in plant cells (Matzke et al. 1989; van der Krol et al. 1990; Napoli et al. 1990) and can occur on both the transcriptional and posttranscriptional levelsjovial 发表于 2025-3-23 09:00:06
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