Range-Of-Motion
发表于 2025-3-25 06:56:27
Sigma Receptors and Alcohol Use Disorders,and it was suggested that their hyperactivity may result in excessive alcohol drinking. This chapter reviews current knowledge on the topic, and suggests that the sigma receptor system may represent a new therapeutic target for the treatment of alcohol use disorders.
Latency
发表于 2025-3-25 07:51:39
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conservative
发表于 2025-3-25 13:37:02
3D Homology Model of Sigma1 Receptor,ation of the virtual 3D Sigma1 receptor model and its reliable applicability to docking-based virtual screening is of significance for rational ligand design, even in light of the recently reported crystal structure for the Sigma1 receptor.
六边形
发表于 2025-3-25 15:53:32
Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors,uously and significantly evolved. With thousands of publications on the subject, these proteins have been implicated in various diseases, disorders, and physiological processes. Nevertheless, we are just beginning to understand what sigma proteins do and how they work. Two subtypes have been identif
松紧带
发表于 2025-3-25 21:18:02
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Control-Group
发表于 2025-3-26 03:45:43
3D Homology Model of Sigma1 Receptor,cability of this structure to docking-based virtual screening and discuss combined in silico/in vitro mutagenesis studies performed to validate the structural features of the Sigma1 receptor model and to qualify/quantify the prominent role of specific amino acid residues in ligand binding. The valid
Picks-Disease
发表于 2025-3-26 07:40:05
,Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Reled by two hydrophobic regions, representing the pharmacophoric elements. The development of computer-based models like the 3D homology model is described as well as the first crystal structure of the σ. receptor. The second part focuses on the synthesis and biological properties of different σ. rece
发酵剂
发表于 2025-3-26 11:26:46
,Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases,le communication, in part through its chaperone activity. In vivo, agonists of the σ. receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological conditions, σ. receptor agonists can induce cytoprotective responses. These protective responses
合唱队
发表于 2025-3-26 13:35:24
Sigma-1 Receptor and Neuronal Excitability,lved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the transmission of information within brain circuits. This versatility may also explain why the Sig-1R
寒冷
发表于 2025-3-26 18:53:16
Sigma-1 Receptor and Pain,nd/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ.R) in nociception, mainly based on the pain-attenuated phenotype of σ.R knockout mice and on the antinociceptive effect exerted by σ.R antagonists on pain of different etiology,