SOW 发表于 2025-3-26 20:56:46
Reduction of Bleomycin-Fe by Reductases and Active Oxygen Formation,ated bleomycin”. induces DNA strand breaks and malondialdehyde (MDA) formation which originates from the oxidative cleavage of deoxyribose (Fig. 1). “Activated bleomycin” may be formed by low molecular reducing agents., but also by enzymatic reduction of bleomycin-Fe(III).. We wondered whether NADPHFantasy 发表于 2025-3-27 02:14:36
Redox Activation of Drugs by the Red Blood Cell Membrane,ted by undesired side effects, of which cardiotoxicity is the most serious. In spite of 20 years of intensive research the action mechanism of these compounds . still remains uncertain.. This is not due to a lack of known effects; on the contrary, the anthracyclines participate in a multitude of intCarbon-Monoxide 发表于 2025-3-27 05:47:38
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Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles,gions in solid tumours. The model for the action of these drugs involves metabolic reduction, with some species produced by that reduction being biologically active. The selectivity arises since high concentrations of oxygen inhibit reduction, the one electron reduction product transferring its extrBILL 发表于 2025-3-27 19:43:13
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,Does Ro 03–8799 Concentration in Human Tumour Xenografts Predict Radiosensitization? Comparison wittal results were promising, most of the clinical trials performed with metronidazole or misonidazole were unable to demonstrate a radiosensitizing effect of these drugs. These disappointing clinical results have been attributed largely to the fact that doses administered to patients were limited tofatty-streak 发表于 2025-3-28 13:54:15
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