Pigeon
发表于 2025-3-30 09:07:05
Ubiquitin–Proteasome System in the Hallmarks of Cancercated in the regulation of various biological and pathological phenomena. Malignant cells utilize modified ubiquitination to augment or attenuate signaling pathways on the basis of whether the outcome of this signaling is conducive or not for tumor growth and survival. Hence, there lies a necessity
ADAGE
发表于 2025-3-30 14:22:55
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折磨
发表于 2025-3-30 19:38:21
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agitate
发表于 2025-3-31 00:27:58
Proteases and Their Role in Drug Development with an Emphasis in Cancertion by regulating the activities of growth factors/cytokines and signalling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. With strong evidence of protease involvement in cancer, proteases serve an im
Blood-Clot
发表于 2025-3-31 01:00:20
Role of Matrix Metalloproteinases in Atherosclerosisinstability. Proposed roles for MMPs included matrix degradation but also regulation of the proliferation, migration and apoptosis of monocytes, macrophages and vascular smooth muscle cells. Accordingly, in vitro and in vivo studies have demonstrated that individual MMPs are utilised by distinct cel
馆长
发表于 2025-3-31 08:30:17
The Importance of the Urokinase-Type Plasminogen Activator and Its Receptor for the Development and iated with several acute and chronic pathologic conditions. uPA mediates extracellular matrix (ECM) degradation and plays a pivotal role in cell adhesion, migration, and proliferation during tissue remodeling. On the cell surface, uPA binds with high affinity to its receptor, the uPAR, providing a s
ALOFT
发表于 2025-3-31 10:21:54
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minimal
发表于 2025-3-31 15:38:23
Regulation of Proteolysis in Vascular Remodelingycans, and water. Matrix–cell adhesion provides essential cell survival cues and the matrix sequesters various growth factors that can regulate the behavior of adjacent cells. However, the matrix, and in particular, the basement membrane, presents a confining barrier that limits vascular cell moveme
比目鱼
发表于 2025-3-31 18:09:06
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