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Zidovudine, Lamivudine, and Abacavir,ot only because it was the first Food and Drug Administration (FDA)-approved agent for the treatment of HIV, but for the unprecedented speed with which this drug moved through the new-drug approval process (Table 1). In March 1987, ZDV was approved by the FDA for use in HIV-infected individuals withradiograph 发表于 2025-3-22 05:36:09
Stavudine, Didanosine, and Zalcitabine,nd in 1987, researchers logically turned to other nucleoside analogs in an attempt to expand the armamentarium against the disease. The next three compounds in this class to become commercially available were didanosine (as Videx®, Bristol Myers Squibb) in 1991, zalcitabine (as Hivid®, F. Hoffmann-LLament 发表于 2025-3-22 12:46:08
Emtricitabine,ering only in having a fluoride at the 5-position of the cytosine ring. Emtricitabine is the (& minus) enantiomer, which is more active than the (+) enantiomer. Emtricitabine has a long plasma half-life (10 h), and even longer intracellular half-life of the active triphosphate (39 h), supporting onc依法逮捕 发表于 2025-3-22 16:16:06
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