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debble 发表于 2025-3-28 03:42:16

Ageing of the human retinal pigment epitheliumce of photoreceptor cells. With increasing age, the RPE is seen to undergo structural changes, lose melanin (its light absorbing pigment), accumulate the age pigment lipofuscin, have reduced antioxidant capacity and progressively accumulate deposits on, and within, the underlying Bruch’s membrane. T

聋子 发表于 2025-3-28 09:12:55

Sub-RPE deposits might be related to defective ubiquitin-dependent proteolysisaminar deposit (BLD), especially, are considered of major importance in the pathogenesis of disciform age-related macular degeneration, and it has been speculated that certain components within these structures might be responsible for subretinal neovascularization. At present, however, not even the

Allege 发表于 2025-3-28 14:17:32

Selective damage on retinal pigment epithelium causes photoreceptor cell death by apoptosis are known to affect the pigment epithelial cells primarily. or to affect the neurosensory retina and damage the RPE secondarily.. When the physiological functions of the pigment epithelium are altered the overlying retina is also affected, resulting in a decrease of visual function.
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查看完整版本: Titlebook: Retinal Pigment Epithelium and Macular Diseases; Gabriel Coscas,Felice Cardillo Piccolino Book 1998 Springer Science+Business Media Dordre