dura-mater 发表于 2025-3-26 23:05:09
Disturbed Matrix Metalloproteinases Activity in Age-Related Macular Degenerationression in MMPs and their tissue inhibitors (TIMPs) are associated with age-related macular degeneration (AMD). Here, we review the evidence for MMPs’ role in the onset and progression of AMD via addressing their regulation and TIMPs’ significant regulatory functions.旧病复发 发表于 2025-3-27 03:15:20
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Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration remains about the genes . and ., at the Chr 10q26 locus. Since both genes are in strong linkage disequilibrium, assigning individual gene effects is difficult. In this chapter, we review current literature about . and . and their relevance to AMD risk. Future studies will be necessary to unravel the mechanisms by which they contribute to AMD.食道 发表于 2025-3-27 12:26:05
Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1Alpha (PGC-1α): A Transcriptional Reguoxidative phosphorylation, and response to oxidative injury. Perturbation of PGC-1α activity in mice causes AMD-like RPE and retinal pathology. There is potential for therapeutic modulation of the PGC-1α pathway in AMD treatment.细丝 发表于 2025-3-27 17:08:36
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The Noncanonical Role of Complement Factor H in Retinal Pigment Epithelium (RPE) Cells and Implicatiearly stages of AMD, and progressive RPE atrophy leads to photoreceptor death and visual impairments that ultimately manifest as geographic atrophy (GA), one of the late-stage forms of AMD. AMD is caused by a combination of risk factors including aging, lifestyle choices, and genetic predisposition.cultivated 发表于 2025-3-28 12:40:21
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