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Mechanisms Driving Resistance to Proteasome Inhibitors Bortezomib, Carfilzomib, and Ixazomib in Mulecome a mainstay of myeloma therapy, significantly enhancing the overall survival of patients. However, bortezomib resistance continues to be a significant hurdle in the treatment of MM, despite the introduction of next-generation PIs such as carfilzomib and ixazomib. Unlike resistance to some other