lexicographer 发表于 2025-3-21 19:40:25
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isted and straight filaments, respectively. They appear as a major tau doublet (tau64 and 69). Some forms of hereditary fronto-temporal dementia also display these tau features. Finally, in Pick’s disease, only 3R-tau isoforms aggregate into random coiled filaments. They are characterized by anotherabracadabra 发表于 2025-3-22 14:29:13
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ed Tau self-interaction leading to increased filament formation has been shown in vitro for the P301L, V337M and R406W mutations, suggesting that at least two properties of Tau may be disturbed by the conformation change induced by the majority of FTDP-17 . missense mutations..Mutations in the 5′ sp消耗 发表于 2025-3-22 21:47:06
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