衍生
发表于 2025-3-26 21:50:19
Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factorsenocysteine incorporation occurs cotranslationally at UGA codons in a subset of messages in prokaryotes, eukaryotes, and archaea. UGA codons are recoded to specify selenocysteine, rather than termination, by the presence of specialized .- and .-acting factors. Here we discuss the mechanism of seleno
立即
发表于 2025-3-27 02:59:03
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Cryptic
发表于 2025-3-27 06:37:42
Specification of Standard Amino Acids by Stop Codons which promotes release of the polypeptide and dissociation of the ribosome. However, the efficiency of termination depends of the local context of the stop codon. In a number of cases, programmed stop codon readthrough occurs allowing the synthesis of two polypeptides from the same mRNA. These even
巧思
发表于 2025-3-27 09:32:03
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剥削
发表于 2025-3-27 13:45:07
Recoding Therapies for Genetic Diseasesh many different genetic diseases. In this chapter we provide an overview of approaches to promote readthrough of premature stop mutations, including pharmacological agents and suppressor tRNAs. We also describe the use of oligonucleotides to induce differential splicing to exclude disease-causing m
变化无常
发表于 2025-3-27 17:54:41
Pseudoknot-Dependent Programmed —1 Ribosomal Frameshifting: Structures, Mechanisms and Modelsshifting occurs in response to specific signals in the mRNA; a slippery sequence, where the ribosome changes frame, and a stimulatory RNA secondary structure, usually a pseudoknot, located immediately downstream. During the frameshift the ribosome slips backwards by a single nucleotide (in the 5′-wa
Tinea-Capitis
发表于 2025-3-27 22:53:43
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自传
发表于 2025-3-28 04:37:42
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不理会
发表于 2025-3-28 08:50:59
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Hippocampus
发表于 2025-3-28 13:51:07
Recoding in Bacteriophageso overlapping tail genes, and both the shifted and unshifted products have essential roles as chaperones of tail assembly. This class is remarkable for the widespread conservation of a frameshift mechanism in the absence of conservation of the direction or magnitude of the shift. The second class of