参考书目
发表于 2025-3-23 12:53:41
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induct
发表于 2025-3-23 16:37:43
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悄悄移动
发表于 2025-3-23 18:57:26
Rational Drug Design978-1-62703-008-3Series ISSN 1064-3745 Series E-ISSN 1940-6029
animated
发表于 2025-3-23 23:08:31
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懦夫
发表于 2025-3-24 05:52:28
https://doi.org/10.1007/978-1-62703-008-3ATP binding; GTPases; Structure based virtual screening; anti-sense microRNA; drug discovery; drug resist
可触知
发表于 2025-3-24 10:35:09
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图画文字
发表于 2025-3-24 12:18:32
Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt Virtual ligand screening is a powerful technique to identify potential hits of targets and to increase hit rates. Here, we describe how we used this technique combined with NMR .N HSQC experiments to obtain small molecules that bind to the PDZ domain of Dvl targeting the Wnt signaling pathway.
genesis
发表于 2025-3-24 18:14:12
Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive ConformatRecent interest in inactive kinase conformations has generated the need to develop new biochemical tools to study them. Here, we describe the use of a fluorescent probe that selectively and potently binds to a specific inactive conformation of protein kinases. This allows for the thermodynamics and kinetics of ligand binding to be determined.
transplantation
发表于 2025-3-24 20:47:07
Yi ZhengAids scienctist in further study of rational drug design.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes suppleme
ungainly
发表于 2025-3-25 01:28:06
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