DNR215 发表于 2025-3-25 06:31:48
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Structure-Based Discovery of Small Molecules Binding to RNA, to use this information for the design of new ligands. Two methods that make heavy use of structural knowledge for ligand discovery are molecular docking and fragment screening. In molecular docking the structure of the binding site is used as a template for the design of new ligands using computatantenna 发表于 2025-3-25 22:05:07
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Messenger RNA as a Novel Therapeutic Approach,y, the perceived shortcomings of mRNA with regard to stability and immunogenicity. Advances in several areas have recently prompted a reexamination of such dogma. Significant improvements in oligonucleotide delivery have been realized over the past decade and their application to mRNA has enabled a