神圣在玷污 发表于 2025-3-23 10:28:26
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miRNAs and Their Emerging Role in Cardiac Hypertrophyf targeted messenger RNAs (mRNAs). More than one-third of human protein-coding mRNAs are predicted as being regulated by miRNAs, which have been implicated in processes as diverse as cancer and muscle biology. Now, recent studies demonstrate that the expression profiles of many miRNAs change duringExpostulate 发表于 2025-3-23 18:49:56
MicroRNAs and the Control of Heart Pathophysiologynt class of gene regulatory molecules in multicellular organisms, and are being implicated in an increasing number of biological processes. Many miRNAs are expressed in a tissue-specific manner during development and take part in the regulation of cell-lineage decisions and morphogenesis. Moreover,蚊帐 发表于 2025-3-24 00:40:42
MicroRNA Systems Biologytrast, RNAs have been thought as molecules which are only transferring genetic information for protein production. Recently, microRNAs (miRNAs) have emerged as another layer of gene regulation. They regulate many key biological processes, including cell growth, death, development and differentiationLethargic 发表于 2025-3-24 05:09:58
Targeting Viral Heart Disease by RNA Interferenced an important cause for VHD in both populations. VHD may lead to dilated cardiomyopathy and heart failure which can ultimately require heart transplantation. However, no specific treatment modality is so far available. We and others have shown that coxsackieviral replication and cytotoxicity can beArthritis 发表于 2025-3-24 09:05:07
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Cardiac Delivery of Nucleic Acids by Transcriptional and Transductional Targeting of Adeno-Associateficiency of cardiac transfer. Efficient and sustained cardiac delivery in large animal models and finally clinical trials requires transfer of vectorized shRNA with suitable application systems. Packaging shRNA constructs in targeted adeno-associated viral (AAV) vectors may be versatile for systemic激励 发表于 2025-3-24 23:05:14
Characterization of Hammerhead Ribozymes Potentially Suitable for the Treatment of Hyper-Proliferatirhead ribozymes were the first type of nucleic acid based drugs to be extensively studied and predicted to be of potential practical utility. These are catalytic RNA molecules capable of inducing the site-specific cleavage of a phosphodiester bond within an RNA molecule. Thus, they can be used to reDALLY 发表于 2025-3-24 23:30:02
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