PON 发表于 2025-3-23 12:28:07
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M. Kŭchař,V. Rejholec,V. Rábek,B. Brůnová,O. Němecěk遗忘 发表于 2025-3-23 20:34:13
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On the Parabolic Relationship Between Biological Activity and Hydrophobicity of Drugs: Transport or ce may be due to transport processes, but it may also be due to hydrophobic interactions with a recepting protein . The purpose of the present paper is to discuss some criteria which may be helpful to discriminate between these two possibilities and, furthermore, to show that hydrophobic interlacrimal-gland 发表于 2025-3-24 08:09:28
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Substructural Analysis in Drug Designted with the names of Hansch and Free and Wilson . A severe limitation shared by these methods is their restriction to structurally closely related series of compounds. Thus they are inappropriate for: a) correlation of data where compounds fall into many different structural series or into nADOPT 发表于 2025-3-24 20:17:32
Stucture-Activity Relationships in a Series of Cinnamic Acids in the Stabilizing Action on Erythrocyn view of the marked antiinflammatory activity found in arylaliphatic acids, we synthesized a series of cinnamic acids substituted on the aromatic ring and branched in the α-position in relation to the carboxyl group (Fig. 1). These compounds were concurrently tested for both antiinflammatory activiungainly 发表于 2025-3-25 01:36:16
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